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Anti-fungal and Bacterial analysis of compounds
4-(2-chloro-6-substitutedquinolin-3-y1)-3-chloro-1-{443-(4-substituted phenyl)-
acrylolyll-phenyl}-azetidine-2-ones |
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| Paper Id :
18015 Submission Date :
2023-08-22 Acceptance Date :
2023-08-22 Publication Date :
2023-08-25
This is an open-access research paper/article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For verification of this paper, please visit on
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| Abstract |
The newly synthesized final compounds were analysed for their work in vitro antibacterial and antifungal activities against many strains Fungas and Bacteria. Preliminary results was Found and indicated that most of the compounds performed/demonstrated very good antimicrobial activity. The synthesis derivatives(4-(2-chloro-6-substituted¬quinolin-3-y1)-3-chloro-1-{443-(4-substituted phenyl)- acrylolyll-phenyl}-azetidine-2-ones) were screened for antibacterial, antifungal, and antiacetylcholinesterase activities in vitro
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| Keywords | Anti-fungal, Bacterial Analysis. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Introduction | Thus a large variety of organic compounds like quinones, Schiff
basesi°, phenols organometallic comp. organophosphorus11-13 group of compound
exhibit diverse biological activity like fungicides, insecticides14
pesticidesI5-16 plant growth regulatois17 antibiotic's, enzymatic
aldolizationl° anti-cancer agents2° and oxygen carriers in biological systems.
Keeping the above facts in mind. It has been decided to study the
anti-bacterial activity of synthesized new chalcones. Common types of bacteria
are given non-scientific names according to their shapes, cell groupings,
ability to form spores and reaction to some special stains. The most important
of these special method of staining is the gram stain. It is a differential
stain, since it colors some bacteria the original purple color and others the
color of the counter stain, usually pink. Those that keep the purple stain are
called gram positive and those take the counter ,stain are called gram
negative'.Escherichia coli. It is gram —ye bacteria lives in intestinal tract
of human beings and many other higher animals. E. coli is the best known
prokaryotic cell. The growth characteristics of E. coli can be . |
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| Objective of study | This paper describes the Anti-fungal and Bacterial analysis
of compounds
4-(2-chloro-6-substituted¬quinolin-3-y1)-3-chloro-1-{443-(4-substituted
phenyl)- acrylolyll-phenyl}-azetidine-2-ones. |
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| Review of Literature | A
fungi' lacking in chlorophyll, cannot synthesize their essential food
requirements. They have therefore to be dependent of food already
synthesized by other plants. Bacteria,2'3 like
fungi are devoid of chlorophyll with a saprophytic or parasitic mode of
like and are unable to synthesize their food requirements from organic
substances.
A large
number of chalcones derivatives have been used as a bactericidal and
fungicidal agents It was found that the chalcones derivatives have been
found more active against4,5,6 8, enzymes4'5'6, bacteria
, and fungi 9. |
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| Methodology |
In this method graded dilutions of the test compounds in a suitable nutrient medium are inoculated with the organism under examination using aseptic techniques and incubated under suitable conditions in an incubator. The minimum concentration of the compound preventing detectable growth (MIC) is taken and a measure of biocidal activity.
In this method following steps are involved :
(a) Sterilization of glass-ware
(b) Preparation of culture media.
(c) Sterilization of culture media
(d) Preparation solution of New chalcones
(e) Determination of MIC values |
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| Result and Discussion |
Table-4.1: Antimicrobial Activity of 4-(2-chloro-6-substitutedquinolin-3-y1)-3-chloro-1-{443-(4-substituted
phenyl)- acrylolyll-phenyl}-azetidine-2-ones.
Cont...Antimicrobial Activity of
Cont...Antimicrobial Activity of
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| Conclusion |
From the result it is evident that most of the compound are
very weekly active and few moderately active against Staphylococcus and
Escherichia coli but compounds R3-Ar¬C1(p), R4-Ar-N(Me)2 (p), R4-Ar-N(C2H5)2
(p) possess very good activity against fungi A. niger and compound R3-Ar-OMe
(p), R2-Ar-N (Me)2 (p), R2-Ar-N(C2H5)2 (p) compound showedmoderate activity all
bacteria and fungi tested. |
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| References | 1. W.E. Autoline, J.M. Knight and D.H. Petering, J. Med.
Chem., 19, 329 (1976). 2. T. Ramakrishna; J. Jackson and W.E. Levinson, Bio.
Inorganic Chem., 9, 23 (1978). 3 E.S. Higgins, D.A. Richert and W.W. westerfeld; J. Nuture,
59, 539-559 (1956). 4. A.K.Sengupta and Madhry Goyal; J. Indian Chem. Soc., 60,
766 (1983). 5. R.J. Guest, Chem. Abst. 47, 76304g (1952). 6. S.R. Ames and C.A. Elvehjem; J. Biol Chem., 43, 165
(1946). 7. S. Turian; Z. Allg. Pathol; 14, 388 (1951). 8. M.L. Monaught and E.L. Owen; Intern. Conger. Biochem.
Abstr. of communs. Ist. Congr. England, 304 (1949). 9. Manju Bala; J. of Asian Chem. Soc. 1 (1), (1992). |
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