|
|||||||
Medical Image Analysis using CNN for Detection of Pneumonia X-ray | |||||||
Paper Id :
19071 Submission Date :
2024-07-10 Acceptance Date :
2024-07-21 Publication Date :
2024-07-25
This is an open-access research paper/article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. DOI:10.5281/zenodo.13761792 For verification of this paper, please visit on
http://www.socialresearchfoundation.com/remarking.php#8
|
|||||||
| |||||||
Abstract |
This paper explores the
utilization of Convolutional Neural Networks (CNNs) for pneumonia detection in
chest X-ray images within the domain of medical image analysis. The importance of
automated tools in aiding disease detection is emphasized, considering the
significant progress CNNs have shown in disease detection and image
segmentation. The CNN architecture effectively captures intricate features in
medical images, leveraging large datasets and backpropagation algorithms to
provide accurate predictions. Data augmentation techniques enhance model
performance and generalization, while the methodology encompasses data
collection, preprocessing, and CNN model selection. Model training and
evaluation are facilitated by using the Adam optimizer and evaluation metrics
like binary cross-entropy loss and accuracy. Python libraries including NumPy,
Matplotlib, Keras, and TensorFlow play essential roles in data manipulation and
model development, with Google Colab serving as a convenient platform for
experiments. The study highlights the potential of CNNs in advancing healthcare
diagnostics, with continued research promising more efficient automated tools
for disease detection. Notably, CNNs excel in discerning patterns in medical
images, particularly in pneumonia detection, contributing to the advancement of
medical imaging and deep learning. The paper discusses the limitations of the
study, such as the relatively small dataset used for training and evaluation,
and suggests future directions, including collecting larger datasets and
extending the CNN model to handle multi-class classification or severity
estimation. |
||||||
---|---|---|---|---|---|---|---|
Keywords | Pneumonia, Deep Learning, CNN, Disease detection, Google Colab. | ||||||
Introduction | In the field of
health care medical images are important for disease diagnosis and prognosis. The
images are told about the patients’ health whether the particular Patient is infected
by any disease or any other healthcare issue. In the medical field there are several
categories of medical images is existed, some of the medical images are MRI, CT
scan, X-ray, Ultrasonography and many more. The images are mainly interpreted
by a professional radiologist or physician. Among these techniques, one of the
oldest and most famous is X-ray imaging technology, which produces images of
different dense body parts like broken bones, pneumonia, or COVID detection
using ionizing radiation techniques. Doctors' ability to see inside the body to
diagnose and treat a variety of illnesses has resulted in a revolution in
medical imaging. Imaging techniques can be used to detect a variety of
conditions without using invasive procedures, which also lessens the need for
such procedures, but the manual detection of the disease through these images
also has several issues. It takes lots of time, and each image must be examined
carefully by the professional doctors. Sometimes the same image may be
interpreted differently by different observers, which can cause discrepancies
and possibly manual errors in diagnosis. Overall, the limitations of the manual
analysis highlight the demand for automated and computer-added tools to
decrease the chance of discrepancies. That’s why in this project we are using a
deep learning algorithm for medical image analysis. Deep learning, an
artificial neural network comprising interconnected nodes and weights, utilizes
computational methods across multiple processing layers to comprehend the
complexity and dimensions of large-scale data. It encompasses probabilistic
models, neural networks, and both supervised and unsupervised learning.
Successfully applied in various fields such as computational biology, medical
imaging, natural language processing, and computer vision, deep learning excels
in medical image analysis. Its automated techniques for segmenting images and extracting
features yield highly accurate predictions, particularly in disease detection
and segmentation. Notably, deep learning models can recognize patterns in
medical images that are challenging to discern manually, enhancing disease
identification accuracy. In the analysis of X-ray images, deep learning employs
large datasets of labeled images, such as pneumonia X-ray datasets sourced from
platforms like Kaggle. For instance, a study utilized 5,863 X-ray images from
pediatric patients aged one to five years, obtained from Guangzhou Women and
Children’s Medical Center. Pneumonia, characterized by fever and respiratory symptoms, impacts mortality rates, particularly in children under five. It manifests as bacterial or viral/fungal pneumonia, with bacterial pneumonia being more severe. Streptococcus pneumoniae is a common cause of community-acquired pneumonia (CAP). Other bacteria like Haemophilus influenza and viruses such as influenza and COVID-19 also contribute. X-rays aid in pneumonia detection, with radiologists employing computer-aided diagnosis (CAD) for analysis using advanced image processing and deep learning algorithms. Deep learning, a branch of artificial intelligence inspired by the human brain, utilizes multi-layered artificial neural networks to address complex problems in various fields (figure1). Also referred to as representational learning (RL), it demonstrates proficiency in applications such as image classification, text mining, and spam detection. Recent advancements in deep learning, particularly in areas like Natural Language Processing (NLP) and Speech Recognition, have exhibited significant performance improvements. In the realm of image analysis, Convolutional Neural Networks (CNNs) are widely employed, comprising layers of filters. These filters progressively identify intricate features within images, starting from basic edges to intricate forms and textures. For example, in our research focusing on pneumonia detection, CNNs are employed. They excel in discerning relevant patterns within medical images, assisting in the precise diagnosis of conditions like pneumonia. CNNs learn to recognize increasingly sophisticated characteristics through the layers of filters, enhancing their efficacy in image analysis tasks. |
||||||
Objective of study | 1.
Preprocessing the X-ray dataset collected from the Kaggle database. 2. Applying
data augmentation techniques such as horizontal flips and random zooming to
enhance the training data. 3. Constructing
a CNN model architecture using TensorFlow and Keras API for accurate pneumonia
detection. 4. Compiling
the model with the Adam optimizer and binary cross-entropy loss function. 5. Training the
model on the available dataset and assessing its performance through
evaluation. 6. Testing the trained model on new X-ray images to ensure its accuracy and reliability. |
||||||
Review of Literature | Data set Literature:
Kermany et al., 2018 Creating a tool for screening of the patients with common blinding retinal
diseases and also demonstrated the general applicability of the AI system on the X-ray of
pneumonia. For this they used transfer learning techniques which trains the neural network
conventional approaches.
Manual Detection:
Bourcier et al. 2014 The use of bedside lung ultrasound by emergency physicians for the
diagnosis of acute pneumonia is the focus of this study. The authors conducted an observational
single-center study involving 144 adult patients and compared the ultrasound examination
performed by trained emergency physicians with chest radiography interpreted by a radiologist.
The results revealed a higher sensitivity (95%) for lung ultrasound compared to chest X-ray
(60%), particularly within the first 24 hours of pneumonia onset. When CT scans were used in
cases of diagnostic difficulty, lung ultrasound demonstrated a 100% performance in diagnosing
acute pneumonia. These findings suggest the potential of lung ultrasound as a first-line imaging
modality for pneumonia diagnosis, with comparable results to previously published studies.
However, limitations include false-positive results and the challenge of detecting deep alveolar
lesions. To improve accuracy, combining lung ultrasound with transthoracic cardiac ultrasound
or evaluating for thrombosis has been proposed. Overall, the study emphasizes the superiority
of lung ultrasound over chest X-ray and proposes its integration into the diagnostic algorithm
for acute pneumonia in the emergency department setting.
CNN Researches:
Gulshan et al., 2016 this study presents an important contribution to the field of medical
imaging and diabetic retinopathy detection. The authors focus on developing a deep learning
algorithm specifically designed to identify signs of diabetic retinopathy through retinal fundus
photographs. The strength of this research lies in the thoroughness of the development and
validation process. The study meticulously detail the steps taken to train and fine-tune their
deep learning model using a large dataset of retinal fundus photographs, including appropriate
data augmentation techniques and model optimization strategies. The rigorous evaluation of
the algorithm's performance on an independent test set adds to the credibility of the study. The
dataset they are used that are obtained from the United States and 3 eye hospitals in India
(Aravind Eye Hospital, Sankara Nethralaya, and Narayana Nethralaya).
Institute of Electrical and Electronics Engineers, n.d, 2018 in this study they used 163 infected
patients CT scan images and 372 non infected images. demonstrates a well-designed
methodology that combines the power of Convolutional Neural Networks (CNN) and Regions
with CNN Features (R-CNN) for accurate detection and classification of lung abnormalities.
By leveraging the strength of CNNs in feature extraction and R-CNNs in localizing regions of
interest, the proposed approach achieves impressive results in terms of both sensitivity and
specificity.
Rahman et al., 2020 The research paper titled "Transfer Learning with Deep Convolutional
Neural Network (CNN) for Pneumonia Detection Using Chest X-ray" explores the application
of transfer learning and deep convolutional neural networks (CNN) in the context of pneumonia
detection from chest X-ray images. This study aim to enhance the accuracy and efficiency of
pneumonia diagnosis, which is of great significance in healthcare. for this study the dataset
divided into 3 category Normal, Viral pneumonia, Bacterial pneumonia. For train, evaluate and
testing the data they used MATLAB(2019a). such as AlexNet,ResNet18, DenseNet201, and
SqueezeNet.
Sharmah et al., n.d, 2020 this study was work on the classification and feature extraction of the
chest X-ray using deep learning. For this study they are using chest X-ray from publicly
available database Keggle. The data consist of 5863 images of chest X-ray. The developed
CNN model in this work that is from scratch to detect pneumonia from the chest X-ray.
L. Chen et al., n.d, 2018 Convolutional neural networks (CNNs) have had a significant impact
on medical image analysis, with the UNet architecture being widely recognized for its success
in semantic segmentation tasks. However, standard convolution layers struggle to capture
distinctive features when differences among categories are subtle. To address this challenge,
the proposed Dense-Res-Inception Net (DRINet) introduces three blocks: a dense connection
block, a residual Inception block, and an unpooling block. Evaluation on a benchmark dataset
shows that the DRINet outperforms the UNet in terms of dice scores, sensitivity, and Hausdorff
distances. The combination of the three blocks offers a trade-off between false negatives (FNs)
and false positives (FPs), resulting in improved overall performance. The DRINet achieves
better segmentation results compared to other CNN architectures, such as Res-U-Net,
particularly in terms of sensitivity, specificity, and Hausdorff distances.
O’Shea & Nash et al., 2015 this paper investigates the application of image-based computer-
aided algorithms for the differential diagnosis of lung abnormalities, such as lung nodules and
diffuse lung diseases. The study proposes the use of convolutional neural networks (CNN) and
regions with CNN features (R-CNN) for image-based computer-aided diagnosis (CADx) and
detection (CADe) of these abnormalities. The results show promising capabilities of CNNbased CADx in effectively distinguishing different types of lung abnormalities and R-CNNbased CADe in successfully detecting these abnormalities. These algorithms eliminate the need
for explicit feature extractors, making them valuable tools for radiologists in diagnosing lung
conditions.
Wolz et al., 2013 This study automatic segmentation of multi organ of human body. It is crucial
for laparoscopy surgery and computer aided diagnosis. For perform this study they used
computer tomography images. The methods are based on registration and weighting scheme of
hierarchical atlas that generate prior specific target.
X. Chen et al., 2012 this study work on a strategic combination of the active appearance model
(AAM), LW, GCs for 3D organ segmentation. The proposed work is divided into three part
model building, object recognition, and delineation. This model takes only 5 minutes for one
organ segmentation. And it is more practical clinical application.
L. Chen et al., 2019 this study work on classification, localization, and segmentation. They
used computer tomography images, 2D ultrasound images, and brain tumors in multi-modal
MR images for this study. it is a compelling research contribution in the field of medical image
analysis. The novel combination of self-supervised learning and image context restoration
techniques shows promise for addressing the limited annotated data challenge in the medical
domain. The study clear explanation, thorough evaluation, and insightful discussions make it a
valuable resource.
Multilevel Feature Extraction and X-Ray Image Classification, n.d et al., 2007 The
classification of the x-ray images. The worked method includes texture feature, shape feature,
combine visual feature, support vectors machine, k nearest neighbors. The used data is a 9000
training images and 1000 test images. This the unique method for automated classification of
medical Images. |
||||||
Methodology | This study aims to develop an effective approach for pneumonia detection in X-ray images
using convolutional neural networks (CNN). The dataset used for this research is collected
from the Kaggle database, which contains a large number of X-ray images of patients
diagnosed with pneumonia. The methodology encompasses data preprocessing, model
architecture selection, training, and evaluation to achieve accurate and reliable results and also
use google colab as interface for python.
Data collection:
The dataset used for this study has been downloaded from the Kaggle database. The dataset
contains 5,863 X-ray images of retrospective cohorts of pediatric patients that were validated
and submitted to the Kaggle database by Guangzhou Women and Children’s Medical Centre,
Guangzhou. The images are divided into three categories Train data, Test data, validation data.
Data augmentation:
The data augmentation is to enhance the diversity and robustness of the training and test dataset.
Data augmentation technique was applied using the ImageDataGenerator class from the keras
library. The training data was augmented by performed horizontal flips and applied random
zooming with a range of 0.2. Training data was generated in batches using
flow_from_directory function, specify the target size of images, batch size, and binary class
mode. Data augmentation helps in increasing the variability of the training samples, enabling
the CNN model to learn more generalizable features and improve its performance.
Create the model:
CNN Model Architecture: In this research the CNN model was implemented using Tenserflow
and keras API in python. The model was defined as a sequential, indicating that the layers are
stacked sequentially. This model architecture was consisting of Convolution layer, Maxpool
layer, Flatten layer, Dense layer with ReLu activation function, But the last layer which is
called Dense layer have 1 unit and sigmoid activation function because of the classification
between pneumonia and normal (figure 2). Fig.2. CNN Model Model compilation & summary:
The compiled model utilizes the Adam optimizer, a widely used algorithm for neural network
training. It adjusts the learning rate dynamically, enhancing the model's weight updates
efficiency. Binary cross-entropy serves as the chosen loss function, apt for binary classification
tasks like distinguishing pneumonia cases from non-pneumonia in X-ray images. Accuracy is
the metric employed to assess the model's performance, indicating the proportion of correctly
classified samples. The model summary offers a succinct depiction of the CNN architecture
and its parameters, presenting a layer-wise breakdown along with the trainable parameters
count in each layer. This summary aids in grasping the model's complexity and structure,
facilitating the identification of potential optimization areas or issues.
Model Training and Evaluation:
The model was train by using the training dataset that are obtain from the Kaggle database.
model is trained iteratively over a specified number of epochs, with the training data fed in
batches to the model. For training the CNN model we was using the model.fit() function on the
preprocess dataset that was stored in the train_data variable. The epochs parameters was set in
10. That means the number of step (Batches) process of each epoch during the training. This
value may depend on the dataset size and computational resources and the validation steps
parameters was set at 25, it was represented number of steps to be processed in validation after
each epoch. The performance of the trained model can be assessed by various matrices such us
accuracy, precision, recall. This matrices provided ability the model to correctly classify the
pneumonia cases. The confusion matrix, was to visualizes the number of true positives, true
negatives, false positives, and false negatives, for further assess the model's performance and
identity any potential issues. The training and evaluation process is repeatedly performed for
the specified number of epochs, for improving the model's performance over the time.
Test the model:
After creating and trained the model test the model to checked its property working or nor for
this the model was loaded and initialized, leveraging a pre-trained weights file. The image was
preprocessed by resizing them to a suitable size and normalized the pixel value. The loaded
image was passed through the trained model and give us the prediction that the image was
infected by pneumonia or not. And we were also using the Matplotlib visualization tool to saw
the x-ray image. |
||||||
Result and Discussion |
Performance Evaluation:
The CNN model developed for pneumonia detection in X-ray images achieved promising
results in terms of accuracy and reliability. During testing, the model demonstrated a high
accuracy rate, indicating its effectiveness in classifying pneumonia cases accurately. Overall,
the model exhibited a good balance between correctly identifying pneumonia cases and
minimizing false positives (figure 3). Fig.3.Test
accuracy of the model Interpretation of Results:
Our CNN model it is use for automated pneumonia detection by analyzing the features. We
found that oust model focus on the identifying specific regions of the lungs that exhibited
characteristic patterns associated with pneumonia. This indicates that our CNN model is
successfully learned discriminative features for pneumonia detection.
Limitations and Future Directions:
Our study has certain limitations. Firstly, the dataset used for training and evaluation was
relatively small, which may affect the generalizability of the model. Future work should aim
to collect larger datasets to enhance the model's performance and robustness. Secondly, our
study focused on classifying binary pneumonia cases (pneumonia vs. normal), but pneumonia
can have different subtypes or severity levels. Extending the CNN model to handle multi-class
classification or severity estimation would be valuable for clinical applications. This study focuses on utilizing Convolutional Neural Networks (CNNs) for medical image
analysis, specifically pneumonia detection in chest X-ray images. It emphasizes the importance
of automated tools in aiding disease detection. CNNs have shown significant progress in
disease detection and image segmentation within the medical field. The CNN architecture
effectively captures intricate features in medical images. By utilizing large datasets and
backpropagation algorithms, CNNs can provide accurate predictions. Data augmentation
techniques were used to improve model performance and generalization. The methodology
involved collecting data, preprocessing, and selecting a suitable CNN model. Efficient model
training and evaluation were facilitated by using the Adam optimizer and evaluation metrics
like binary cross-entropy loss and accuracy. Python libraries like NumPy, Matplotlib, Keras,
and TensorFlow were essential for data manipulation and model development. Google Colab
served as a convenient platform for experiments. The application of CNNs in medical image
analysis holds promise for advancing healthcare diagnostics. Continued research could lead to
more efficient automated tools for disease detection, benefiting patient outcomes and medical
science. In summary, this study provides insights into CNNs' role in medical image analysis,
particularly in pneumonia detection, contributing to the advancement of medical imaging and
deep learning. |
||||||
Conclusion |
Improved Accuracy and
Generalization: Future research can focus on
improving the accuracy and generalization capabilities of CNN models for
pneumonia detection. This can be achieved by incorporating more diverse and
representative datasets, including cases from different demographics and populations.
Additionally, exploring advanced CNN architectures and optimization techniques,
such as transfer learning and ensemble methods, may lead to enhanced
performance and robustness. Explainability and Interpretability: CNNs are often considered black-box
models, lacking transparency and interpretability. Future research can focus on
developing methods to explain and interpret the decisions made by CNNs in
pneumonia detection. Techniques such as attention mechanisms, saliency mapping,
and visualization of learned features can provide insights into the important
regions and features used by the models for diagnosis. Real-Time Diagnosis: Real-time diagnosis of pneumonia
using CNNs can significantly impact clinical practice by enabling rapid and
early detection. Future research can explore the deployment of CNN models on
edge devices or cloud-based platforms to provide real-time diagnosis,
facilitating timely intervention and treatment. Integration with Clinical Decision
Support Systems: Integration of CNN-based pneumonia
detection models with clinical decision support systems can assist radiologists
and healthcare professionals in making accurate and efficient diagnoses. By
combining the power of AI-driven image analysis with clinical expertise, these
systems can improve diagnostic accuracy, reduce workload, and enhance patient
outcomes. By exploring these future prospects, we can continue to advance the field of medical image analysis using CNNs for the detection of pneumonia in X-ray images, ultimately improving diagnosis, treatment, and patient care. |
||||||
References |
|